[Footnote 1: Arch. f. Path. Anatomie, xlvi., p. 409. Gaz. Med de Paris,
1868, No. 39. Also Journ. de l'Anatomie et de la Physiologie, 1873, p.
398.]
Mayencon and Bergeret have also shown that in men and rabbits the silver
salt administered is quickly distributed in the body, and is but slowly
excreted by the urine and faeces.
Chronic poisoning shows itself in a peculiar coloring of the skin
(Argyria Fuchs), especially in the face, beginning first on the
sclerotic. The skin does not always take the same color; it becomes in
most cases grayish blue, slaty sometimes, though, a greenish brown or
olive color.
Von Hasselt thinks that probably chloride of silver is deposited in
the rete malpighii, which is blackened by the action of light, or that
sulphide of silver is formed by direct union of the silver with the
sulphur of the epidermis. That the action of light is not absolutely
necessary, Patterson states, follows from the often simultaneous
appearance of this coloring upon the mucous membrane, especially that of
the mouth and upon the gums; and Dr. Frommann Hermann[1] and others have
shown that a similar coloring is also found in the internal parts.
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